Can High-Fructose Corn Syrup Make You Hungrier?

Fructose - a kind of sugar found in a wide variety of foods and beverages - may encourage overeating, new research suggests.

Fructose may be best known to consumers in the form of high-fructose corn syrup, which has long been added to manufactured foods from sodas to cookies.

Distinct from sugar known as glucose (produced by the natural breakdown of complex carbohydrates), fructose is also a "simple" sugar and a natural component of fruit.

However, "in a series of studies we have found that when compared to glucose, the simple sugar, fructose, is a weaker suppressor of brain areas that help control appetite and the motivation to eat," said study co-author Dr. Kathleen Page, an assistant professor of clinical medicine at the Keck School of Medicine of the University of Southern California in Los Angeles.

In other words, people are more likely to remain feeling hungry after a meal with lots of fructose versus one with lots of glucose.

Prior research has indicated that, when compared with glucose consumption, ingesting fructose sparks a smaller release of hormones such as insulin that give rise to a sense of being full, according to background information with the study. Recent investigations have also suggested that only glucose, not fructose, curtails hunger by slowing down activity in a specific region of the brain (the hypothalamus), the researchers said.

The small, new study builds on both findings.

More than two-thirds of American adults are overweight or obese, which puts them at risk of heart disease, type 2 diabetes and certain cancers. Many experts believe that changes in U.S. food production, including widespread use of high-fructose corn syrup, are to blame.

For the current effort, the researchers enlisted 24 men and women ages 16 to 25 to participate in a hunger exercise.

All participants were instructed to consume a drink sweetened with either glucose or fructose. Then they were asked to view images of various foods (including, for example, chocolate cake) and indicate the degree to which they felt hunger. The exercise took place while each was hooked up to a functional magnetic resonance imaging (fMRI) scanner in order to track real-time brain activity in a "reward" center of the brain known as the nucleus accumbens.

Hunger was greater among those who had consumed the fructose drink, the authors found. At the same time, the fructose mix provoked greater activity in the targeted brain region, which translated into a greater desire to eat.

However, Page stressed that the current findings are "preliminary." More work is needed before broad conclusions can be drawn about how sweeteners in manufactured food products actually influence hunger and the overall risk for obesity, she said.

For example, "it's important to note that both fructose and glucose are found in almost equal quantities in both high-fructose corn syrup and table sugar," Page said. "We don't yet know whether the brain responds differently to high-fructose corn syrup compared to glucose or sucrose [table sugar]."

And a trade association representing the corn refining industry in the United States countered that the study doesn't reflect real-life consumption.

"The subjects in this study were given large amounts of pure fructose and pure glucose separately, which almost never occurs outside a laboratory setting," the Corn Refiners Association said in a statement. "While those who received pure fructose may have reacted as if they were less sated, these study conditions did not correspond to anything like a natural setting in which people normally would be consuming roughly equal amounts of glucose in combination at the same time."

But Lona Sandon, a registered dietitian and assistant professor of clinical nutrition at the University of Texas Southwestern Medical Center at Dallas, said the study findings are consistent with other research.

"We have known for quite some time that the insulin response to glucose in the bloodstream is a normal response to signal the brain and body that calories have been consumed," Sandon said. "Fructose does not trigger the same response of insulin."

The interplay between glucose and insulin is probably an important part of weight regulation, she added.

The bottom line, said Sandon, is that added sugars bring no nutritive value to foods. Her advice? "Choose whole, nutrient-rich foods and whole grains most of the time."

5 Colorful foods that help lower cancer

An increasing number of studies are showing links between healthy eating habits and the prevention of certain forms of cancer. Moreover, research has found that colorful fresh foods which tend to be high in immune-boosting phytochemicals, are particularly adept at this. Below is a discussion of the different dietary changes that can be made to make sure these phytochemicals are part of the daily diet.

Red foods - Perhaps the best-known of red foods, tomatoes, have been linked to decreased risk of cancer of the ovaries. In a study of some 15,000 women, it was found that eating just a half-cup of tomatoes at least four times a week can lower the chances of developing tumors on the ovaries by a whopping 50%. Consumption of tomatoes was connected in another study to fighting pancreatic malignancy as well. It is thought that this is due to its lycopene, which is also found in red peppers and red berries.

Orange foods - The phytochemicals which lend orange vegetables like squash and carrots their color have been proven to be effective in treating malignancy in the digestive tract. Caffeic acid, found in high quantities in yams, has been proven to slow the development of malignant cells in the breast. Orange fruits and vegetables should be eaten around three times a week.

Yellow foods - Citrus fruits, such as grapefruit, lemons, tangerines and papayas, are excellent means to help ward off tumor formation through the diet. This is because these foods are all high in Vitamin C which has been shown to be extremely effective at fighting digestive cancers, such as those of the mouth, throat and colon. Apart from Vitamin C, they are also high in phyto-compounds that slow the development of tumors and promote overall healing through detoxification.

Green foods - Research has linked the consumption of cruciferous vegetables like broccoli, cauliflower, cabbage, kale, bok choy and endive, to a lower risk of several cancers, including those of the ovaries, stomach and colon. Scientists believe that this is likely due to the fact that these green foods are an excellent source of glucosinolates, which chemicals with anti-cancer properties and Vitamin K, which is particularly effective in reducing the risk of pancreatic malignancies. Try to include them in the diet at least once a day.

White foods - While color-rich fruits and vegetables can ward off cancer, there are many white or pale-colored ones that have that ability, too. They include mushrooms as well as members of the allium family like garlic and onions. Both mushrooms and alliums have been linked to lower rates of digestive cancer. The allium family is high in a chemical called allicin, which is a powerful antioxidant. Onions also contain phytochemicals linked to reduce risk of colon cancer. Mushrooms are a good source of Vitamin D that can lower development of malginancy in the ovaries. Add them to the diet twice a day if possible for maximum effect.

These colorful fruits and vegetables will not only lend interest and flavor to the diet, but also help reduce the risk of developing tumors or to help combat it if it does become established. These foods are also easy to work into a diet in soups, salads, casseroles or fruit-based desserts.

Excellent natural calcium sources for bone health

Calcium is an essential macromineral whose roles in the body are relatively well-known. It strengthens bones and teeth, improves the body's alkalinity, helps our heart muscles to contract and relax properly and more.

Like all minerals, calcium doesn't work alone, but in tandem with other nutrients such as magnesium and vitamin D. For this reason, obtaining our calcium from whole foods - foods whose nutrient profiles have been optimized by nature for superior absorption -- is the best way to remain healthy.

Good natural sources of calcium

Seaweed - It is common to find seaweed in any "best of" list, and for good reason: since seaweed grows in the ocean and is thus unaffected by soil erosion (the process that has significantly reduced the nutritional value of most land-based vegetables), its nutritiousness has remained intact for centuries. And, as it happens, seaweed has always been rich in calcium.

Perhaps the best seaweeds in this regard are kelp, kombu and wakame. One hundred grams of each contain between 150 and 170 grams of calcium, as well as countless other essential nutrients, including iodine. Avoiding seaweed sourced from the Pacific Ocean is a good idea due to possible radiation contamination.

Chia seeds - Though chia seeds are best-known for their high protein and fiber content, they contain similarly impressive levels of calcium. In fact, 1 ounce of these versatile South American seeds provides us with 179 milligrams of calcium, which is 17 percent of our recommended daily allowance (RDA). Of course, it's easy to consume far more than 1 ounce of chia seeds per day, making them one of the easiest foods to consume for correcting a calcium deficiency.

Blackstrap molasses - Blackstrap molasses is the dark, treacle-like byproduct of the sugar cane refinement process. Since it is derived from the sugar cane plant, whose tall roots grow deep into the soil, it contains a large number of nutrients that are seldom found in such quantities elsewhere, including calcium. Specifically, 1 tablespoon of blackstrap supplies us with 123 milligrams of the mineral, or 12 percent of our RDA. Blackstrap is also a good source of magnesium, manganese, selenium, potassium and iron, and makes a great sweetener in baking.

Sesame seeds - These nutty and delicate seeds, which belong to one of the oldest oilseed crops grown on Earth, supply our bodies with 88 milligrams of calcium per tablespoon. Like chia seeds, sesame seeds are incredibly versatile and can be sprinkled on salads and cooked meals, or simply eaten as a snack.

Raw milk - According to the Weston A. Price Foundation, 8 ounces of raw milk - unprocessed milk straight from the cow -- supplies our bodies with 300 milligrams of calcium. Additionally, it contains certain minerals, such as phosphorus and magnesium, which aid the calcium's absorption rate. Unfortunately, milk subjected to homogenization and/or pasteurization does not fare as well. These unnatural processes damage the nutritional structure of the milk, and inhibit the absorption rate of its nutrients.

Incidentally, this fact also applies to other dairy products. Yogurt, cheese and kefir are all excellent sources of calcium when made from raw milk. When made using processed milk, however, their nutrient profile is compromised.

Certain leafy greens - Due to soil erosion, most green vegetables - once considered among the finest sources of calcium -- are now shadows of their former selves nutrition-wise. Fortunately, a number of hardy greens do retain some of their nutritional power. Kale is probably the best example of these (1 cup of chopped kale contains 101 milligrams of calcium), with broccoli and spinach in second and third place respectably.