Study shows blood pressure medication is not linked to breast cancer

Women who take a common type of medication to control their blood pressure are not at increased risk of developing breast cancer due to the drug, according to new study by researchers at the Intermountain Medical Center Heart Institute in Murray, Utah.

Researchers analyzed the records of more than 3,700 women who had no history of breast cancer, and who had long-term use of calcium channel blocker medications to control their blood pressure. Researchers found only a minimal increase in risk in one study and a 50 percent reduced risk in a second, leading them to recommend the continued use of these important medications to help prevent heart attack and stroke.

Calcium channel blockers are commonly used to help prevent calcium from entering cells of the heart and blood vessel walls, resulting in lower blood pressure.

"We found no robust data that calcium channel blocker medications increase a person's risk of breast cancer," said Jeffery L. Anderson, MD, a cardiologist and researcher at the Intermountain Medical Center Heart Institute. "Given the important role calcium channel blocker medications play in treating heart conditions, we think it's premature to discontinue their use. At this point we recommend that patients continue taking these medications to treat their hypertension."

The Intermountain Heart Institute study was in response to a similar study released last year by the Fred Hutchinson Cancer Research Center in Seattle. That study suggested that the odds of getting breast cancer was 2.5 times higher for women who take calcium channel blocker medications. Results of the Intermountain study indicated small to no increased risk.

The Intermountain Medical Center Heart Institute study carefully examined data collected from more than 3,700 women ages 50 to 70 with no history of breast cancer in two Intermountain Healthcare databases. For each group, researchers compared women who were prescribed calcium channel blocker medications to similar women who weren't prescribed the medications.

In their review of a general population medical records database, researchers found the odds of breast cancer to be 1.6 times higher by using calcium channel blockers, which was significant, but much smaller than reported by the Seattle group.

But, in contrast, in the data collected from patients treated in the Intermountain Cardiac Catheterization Laboratory, a reverse relationship was found -- a 50 percent reduction in risk of developing breast cancer for women who took the calcium channel blockers. The contrasting results found in these two independent analyses led researchers at the Intermountain Medical Center Heart Institute to conclude that it is likely not the medication that caused the changes in breast cancer risk but other factors (e.g., selection biases).

Hypertensive patients who have psoriasis may need stricter blood pressure control

People with hypertension who also have psoriasis may benefit from tighter blood pressure control, say researchers, particularly if their psoriasis is moderate or severe.

According to a new study psoriasis is independently associated with poorly controlled blood pressure and those with moderate to severe disease are at the greatest risk of uncontrolled hypertension.

Psoriasis is a chronic inflammatory skin disease and cardiovascular risk factors are known to be more prevalent among people who have the condition. Although previous studies have suggested that psoriasis increases the risk of cardiovascular events, how it affects hypertension control remains unclear.

For the current study, Junk Takeshita (University of Pennsylvania, Philadelphia) and colleagues examined the relationship between psoriasis and blood pressure control among 1,322 hypertensive patients who had psoriasis and 11,977 age-matched controls who had hypertension but no psoriasis. Data were drawn from The Health Improvement Network (THIN), an electronic database of medical records that is broadly representative of the UK’s general population.

Psoriasis severity was assessed according to the surface area of the body affected, with psoriasis classed as moderate or severe when it affected 3% or more of the body area. Uncontrolled blood pressure was defined as a systolic blood pressure of 140 mm Hg or higher or a diastolic blood pressure of 90 mm Hg or higher.

The researchers discovered a significant positive dose-dependent relationship between psoriasis severity and uncontrolled hypertension. Compared with hypertensive patients who did not have psoriasis, those with mild psoriasis were 3% less likely to have uncontrolled hypertension, while those with moderate or severe disease were 20% and 48% more likely (respectively) to have uncontrolled hypertension. These results were obtained after adjustment for age, gender, body mass index, comorbidity, smoking status, alcohol status and the use of blood pressure medications and anti-inflammatory drugs.

The team also found that the patients with psoriasis were no more likely to be receiving any antihypertensive medication than patients without the skin condition and that the likelihood of such treatment being received did not differ according to psoriasis severity.

Yogurt and probiotic-rich foods can help lower blood pressure

A simple way to help keep your blood pressure in check is to consume plenty of probiotic-rich foods like yogurt and kefir, suggest the findings of a new scientific review. While not necessarily a cure for people with heart issues, probiotics have been shown in a multitude of clinical studies to modestly lower blood pressure, as well as balance blood sugar, cholesterol and hormone levels.

This latest investigation into the science behind probiotics found that the combined results of nine randomized, placebo-controlled studies demonstrate heart benefits associated with probiotics. Among 550 participants who took a probiotic or ate a probiotic-rich food, average systolic blood pressure levels dropped by 3.56 millimeters of mercury (mm Hg), while diastolic levels dropped by 2.38 mm Hg, on average.

This is significant, as many blood pressure drugs that perform similar functions come with nasty side effects, none of which are present when taking probiotics. The key, say researchers, is consuming at least 100 billion colony-forming units of probiotics daily, which is roughly the amount found in a small carton of high-quality, authentic yogurt.

"I do not think the general public understands how probiotics might be beneficial to health at this stage," said Jing Sun from the Griffith University School of Medicine and Griffith Heart Institute in Queensland, Australia, lead author of the study. "The challenge to us is to convince patients and clinicians to accept the product in daily life."

Based on the data, taking optimal or higher amounts of probiotics daily for at least two months can produce dramatic benefits, particularly when combined with other interventions like healthy eating and regular exercise. In other words, chowing down on yogurt can be helpful, but it is also important to combine this other healthy lifestyle habits.

Probiotics are a 'functional food' that can prevent chronic illness

Beyond their heart-health benefits, researchers have concluded that probiotics are a full-spectrum "functional food," meaning they offer health benefits beyond basic nutrition. According to Lori Hoolihan, a researcher at the Dairy Council of California in Irvine, probiotics work in many ways to optimize health and prevent chronic diseases.

"Randomized clinical trials are the gold standard in research and they had a strict criteria for choosing the studies and they actually looked at human trials which are stronger than animal trials," she is quoted as saying.

"Americans don't like to think about bacteria so it's hard for people to embrace it but there are good and bad bacteria and there is no avoiding them. Our gut is home to many bacteria and if bumping up the amount of good bacteria can optimize health and prevent chronic diseases then that's a good thing," Hoolihan added.

Other helpful ways to lower blood pressure naturally through diet include reducing carbohydrate and sugar intake, as both of these things contribute to insulin resistance and metabolic dysfunction. Increasing intake of beneficial minerals like potassium, magnesium and calcium, as well as consuming healthy saturated fats like grass-fed ghee, butter, palm oil and coconut oil, is also helpful.

It is also important to increase your intake of omega-3 fatty acids, both through fatty fish consumption and supplementation with omega-3-rich oils like flax, hemp, cod liver and skate liver. Omega-3s have been shown in multiple studies to reduce both systolic and diastolic blood pressure, as well as reduce other risk factors associated with cardiovascular disease.

Concerning probiotics, Sun added:

"We believe probiotics might help lower blood pressure by having other positive effects on health, including improving total cholesterol and low-density lipoprotein, or LDL, cholesterol; reducing blood glucose and insulin resistance; and by helping to regulate the hormone system that regulates blood pressure and fluid balance."

Black beans lower blood pressure, reduce degenerative disease and much more

Black beans contain proteins that act as antioxidants and can lower blood pressure and remove toxic metals from the body, according to a study conducted by researchers from Mexico's National School of Biological Sciences of the National Polytechnic Institute (IPN-ENCB).

Researchers ground up dried black beans, then isolated and hydrolyzed two of the main proteins found in the Jamapa variety of black beans: fasolina and lectin. The proteins were then tested using computer simulations.

They found that the two proteins demonstrated chelating activity, meaning that they removed heavy metals from the body. In addition, when the proteins were hydrolyzed with pepsin-pancratin, they also demonstrated antioxidant and antihypertensive activity.

"With the research we have discovered the essence of the legume, and identified the nutritional components such as carbohydrates, starch, proteins, fats, phenolic compounds that have related antioxidant effects," lead researcher Gloria Davila Ortiz said.

The findings may partially explain why studies have shown beans to be so beneficial for heart health. The researchers expressed hope that their findings could lead to new treatments for preventing and treating cardiovascular disease by targeting oxidative stress and high blood pressure.

"The Jamapa black bean proteins have biological properties and nutrients that help lower glucose, cholesterol and triglycerides," Davila Ortiz said. "Thanks to a collaboration between the IPN and the National Institute of Medical Sciences and Nutrition Salvador Zubiran, diets for people with diabetes were developed and it was found that glucose in blood decreased. In the future we intend to develop products containing proteins which would be aimed at treatment and prevention of diseases, seeking specific effect on blood pressure and as an antioxidant."

Beans form the basis of many diets around the world and are also one of the least expensive foods in terms of both weight and nutrient content. Beans are known to be rich in essential nutrients, with one cup of cooked black beans including fiber (59.8 % of the recommended daily intake), protein (30.4 %), iron (20 %), folate (64 %), magnesium (30.1 %), manganese (38 %), molybdenum (172 %), phosphorus (24 %), tryptophan (56.2 %) and vitamin B1 (28 %).

Soluble fiber, like that found in beans, has been shown to reduce cholesterol levels. Indeed, clinical trials have shown that eating beans (canned or dried) reduces levels of total and LDL ("bad") cholesterol and triglycerides, while increasing levels of HDL ("good") cholesterol.

Beans are also rich in phytonutrients, which are now considered responsible for many of the health benefits of fruits and vegetables. Many of these phytonutrients have antioxidant properties.

According to a study by the U.S. Department of Agriculture, three of the four foods highest in antioxidants are actually beans: the red bean, the red kidney bean and the pinto bean. Another study, conducted by the Colorado State University Department of Soil and Crop Sciences, also found that red beans were highest in antioxidants, but ranked black beans at number two. This study found that antioxidant content was linked with a dark color in the bean's coat, because the pigments in the seed are produced by antioxidant phytonutrients such as phenols and anthocyanins.

Antioxidants remove free radicals from the body and are believed to thereby lower the risk of chronic diseases and slow the effects of aging. Indeed, beans have been linked with many of the health effects associated with antioxidants: a lower risk of diabetes, obesity, degenerative diseases, and a wide variety of cancers.

Watermelon could lower blood pressure, study suggests

Watermelon could significantly reduce blood pressure in overweight individuals both at rest and while under stress. “The pressure on the aorta and on the heart decreased after consuming watermelon extract,” the small study concludes.

Be sure to pick up a watermelon - or two - at your local grocery store. It could save your life.

A new study by Florida State University Associate Professor Arturo Figueroa,found that watermelon could significantly reduce blood pressure in overweight individuals both at rest and while under stress. “The pressure on the aorta and on the heart decreased after consuming watermelon extract,” Figueroa said.

The study started with a simple concept. More people die of heart attacks in cold weather because the stress of the cold temperatures causes blood pressure to increase and the heart has to work harder to pump blood into the aorta. That often leads to less blood flow to the heart.

Thus, people with obesity and high blood pressure face a higher risk for stroke or heart attack when exposed to the cold either during the winter or in rooms with low temperatures.

So, what might help their hearts?

It turned out that watermelon may be part of the answer.

Figueroa’s 12-week study focused on 13 middle-aged, obese men and women who also suffered from high blood pressure. To simulate cold weather conditions, one hand of the subject was dipped into 39 degree water (or 4 degrees Celsius) while Figueroa’s team took their blood pressure and other vital measurements.

Meanwhile, the group was divided into two. For the first six weeks, one group was given four grams of the amino acid L-citrulline and two grams of L-arginine per day, both from watermelon extract. The other group was given a placebo for 6 weeks.

Then, they switched for the second six weeks.

Participants also had to refrain from taking any medication for blood pressure or making any significant changes in their lifestyle, particularly related to diet and exercise, during the study. The results showed that consuming watermelon had a positive impact on aortic blood pressure and other vascular parameters. Notably, study participants showed improvements in blood pressure and cardiac stress while both at rest and while they were exposed to the cold water. “That means less overload to the heart, so the heart is going to work easily during a stressful situation such as cold exposure,” Figueroa said. Figueroa has conducted multiple studies on the benefits of watermelon. In the past, he examined how it impacts post-menopausal women’s arterial function and the blood pressure readings of adults with pre-hypertension.